O-Desmethyltramadol (O-DT) or 3-[2-(1-Amino-1-methylethyl)-1-hydroxycyclohexyl]phenol is an opioid analgesic and the main active metabolite of tramadol. O-Desmethyltramadol is the most important metabolite of tramadol produced in the liver after tramadol is consumed. This metabolite is considerably more potent as a µ opioid agonist than the parent compound. The two enantiomers of O-desmethyltramadol show quite distinct pharmacological profiles; both (+) and (-)-O-desmethyltramadol are inactive as serotonin reuptake inhibitors, but (-)-O-desmethyltramadol retains activity as a noradrenaline reuptake inhibitor and so the mix of both the parent compound and metabolites produced contributes significantly to the complex pharmacological profile of tramadol. O-Desmethyltramadol is metabolized in the liver into the active metabolite N,O-didesmethyltramadol via CYP2D6. The inactive tramadol metabolite N-desmethyltramadol is also metabolized into the active metabolite N,O-didesmethyltramadol by the same enzyme.
The opioid medication tapentadol was developed to mimic the actions of O-desmethyltramadol in order to create a weak-moderate analgesic which is not dependent on metabolic activation. O-Desmethyltramadol has recently been marketed as a currently legal substitute for illegal opioid drugs, either in powder form or mixed into various other preparations. As an opioid analgesic it is well known under the name M1. Its chemical formula is C15H23NO2 . M1 can be taken with or without food as it doesn’t influence its efficiency. It is more efficient that tramadol which is considered one of the strongest pain killers. This Research Chemical is not for human consumption and should be used for chemical research only.